丙型肝炎病毒(基础)【11页】

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丙型肝炎病毒

邢文革

2014-12-17 石家庄

丙型肝炎病毒的发现

•1970’s: Hepatitis A and B diagnostics

–Most transfusion associated hepatitis not caused

by HAV and HBV or other known viral agents (NEJM

292: 767; Gastro. 69:1278; JID 139:511; Vox Sang. 44:231)

•non-A, non-B hepatitis (NANBH)

–Might be a small, enveloped virus transmissible to

chimpanzees (Gastro 88:773; JID 156:636)

–Standard immunological methods failed to identify

viral antibodies or antigens

–Chiron group

•Thought that there was not enough viral antigen in

NANBH

•So they decided to try and concentrate the virus

丙型肝炎病毒的发现

1. 传染性肝炎 (HA)

血清型肝炎 (HB)

2. 动物模型（黑猩猩）

3. 基因文库

4. 放射免疫标记

5. 全基因测序

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标签： #肝炎

摘要：

丙型肝炎病毒邢文革2014-12-17石家庄丙型肝炎病毒的发现•1970’s:HepatitisAandBdiagnostics–MosttransfusionassociatedhepatitisnotcausedbyHAVandHBVorotherknownviralagents(NEJM292:767;Gastro.69:1278;JID139:511;VoxSang.44:231)•non-A,non-Bhepatitis(NANBH)–Mightbeasmall,envelopedvirustransmissibletochimpanzees(Gastro88:773;JID156:...

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